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肠道中血清素的浓度及其释放的影响因素。

Concentration of serotonin in intestine and factors affecting its release.

作者信息

Gross K B, Sturkie P A

出版信息

Proc Soc Exp Biol Med. 1975 Apr;148(4):1261-4. doi: 10.3181/00379727-148-38729.

DOI:10.3181/00379727-148-38729
PMID:1129340
Abstract

The concentration of serotonin in the female chicken intestine (10.79 mug/g wet tissue) was significantly higher than in the male (7.98 mug/g). The release of serotonin from an isolated perfused intestine was studied. The intestine continually releases serotonin at the rate of 10 ng per g/min. A number of substances, including glycine, epinephrine, and acetylcholine, caused a significant release of serotonin, with acetylcholine having the greatest effect. Histamine or electrical stimulation did not affect the release of serotonin.

摘要

雌性鸡肠道中血清素的浓度(10.79微克/克湿组织)显著高于雄性(7.98微克/克)。对离体灌注肠道中血清素的释放进行了研究。肠道以每分钟每克10纳克的速率持续释放血清素。包括甘氨酸、肾上腺素和乙酰胆碱在内的多种物质会导致血清素显著释放,其中乙酰胆碱的作用最大。组胺或电刺激不影响血清素的释放。

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引用本文的文献

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2
Analysis of anomalous pKb values for metiamide and atropine in the isolated stomach of the mouse.小鼠离体胃中甲硫米特和阿托品异常pKb值的分析。
Br J Pharmacol. 1979 Sep;67(1):59-65.
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Prostaglandins and serotonin: nonpeptide diarrheogenic hormones.前列腺素和血清素:非肽类致泻激素。
World J Surg. 1979 Sep 20;3(5):565-78. doi: 10.1007/BF01654761.