Pezzilli R, Morselli-Labate A M, d'Alessandro A, Barakat B
Emergency Department, Sant'Orsola Hospital, Bologna, Italy.
Eur J Gastroenterol Hepatol. 2001 Mar;13(3):269-74. doi: 10.1097/00042737-200103000-00009.
Urine trypsinogen-2 has been suggested as a marker of damage due to acute pancreatitis. Our aim was to assess the time-course and the clinical value of this test in acute pancreatitis.
A urine trypsinogen-2 dipstick test was performed on 30 patients with acute pancreatitis upon admission to the emergency room, as well as on 30 patients with non-pancreatic acute abdominal pain, and in 30 healthy subjects.
In 53.3% of the patients with acute pancreatitis the dipstick test showed abnormal urine trypsinogen-2 whereas this test gave negative results in all patients with non-pancreatic acute abdomen and in all healthy subjects. Patients with severe acute pancreatitis had a frequency of abnormal results of urine trypsinogen-2 (8/9, 88.9%; 95% CI, 51.8-99.7%) significantly higher (P = 0.031) than those with the mild disease (8/21, 38.1%; 95% CI, 18.1 -61.6%), while no significant differences were found in the urine trypsinogen-2 results between patients with biliary acute pancreatitis and those with non-biliary acute pancreatitis. Regarding the time-course of urine trypsinogen-2, there were no significant differences during the three days of the study.
The specificity of urine trypsinogen-2 in the diagnosis of acute pancreatitis is good however its sensitivity is low.
尿胰蛋白酶原-2已被提议作为急性胰腺炎所致损伤的标志物。我们的目的是评估该检测在急性胰腺炎中的时间进程及临床价值。
对30例急诊入院的急性胰腺炎患者、30例非胰腺性急性腹痛患者以及30例健康受试者进行尿胰蛋白酶原-2试纸条检测。
在53.3%的急性胰腺炎患者中，试纸条检测显示尿胰蛋白酶原-2异常，而该检测在所有非胰腺性急性腹痛患者及所有健康受试者中均为阴性结果。重症急性胰腺炎患者尿胰蛋白酶原-2异常结果的发生率（8/9，88.9%；95%可信区间，51.8 - 99.7%）显著高于轻症患者（8/21，38.1%；95%可信区间，18.1 - 61.6%）（P = 0.031），而胆源性急性胰腺炎患者与非胆源性急性胰腺炎患者的尿胰蛋白酶原-2结果无显著差异。关于尿胰蛋白酶原-2的时间进程，在研究的三天中无显著差异。
尿胰蛋白酶原-2在急性胰腺炎诊断中的特异性良好，但其敏感性较低。
