二氮嗪所致烦渴引起的稀释性低钠血症。

Dilutional hyponatremia due to diazoxide-produced polydipsia.

作者信息

Tang M, Falk J L

出版信息

Pharmacol Biochem Behav. 1975 Jan-Feb;3(1):115-9. doi: 10.1016/0091-3057(75)90089-1.

Abstract

Subcutaneous injection of diazoxide every 3 hr for a total of 5 doses in 15 hr produced a state of elevated drinking and antidiuresis in rats resulting in a massive, positive, self-imposed water load. Dilutional hyponatremia was present, but not serum hyposmolality, owing to the increased serum glucose and BUN. The mechanism by which diazoxide produces a polydipsia even in the presence of an accumulating water load may illuminate the genesis of other pathophysiological dilutional states.

摘要

每3小时给大鼠皮下注射二氮嗪，共注射5剂，在15小时内产生了饮水增加和抗利尿状态，导致大鼠出现大量的、正向的、自我施加的水负荷。由于血清葡萄糖和尿素氮增加，存在稀释性低钠血症，但不存在血清低渗。即使在存在累积水负荷的情况下，二氮嗪产生烦渴的机制可能有助于阐明其他病理生理稀释状态的发生。