Cho J H, Kim G E, Cho K H, Lee C G, Kim Y B, Lee S W, Keum K C, Suh C O
Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 2001 Feb;42(1):55-64. doi: 10.3349/ymj.2001.42.1.55.
To evaluate the efficacy of hyperfractionated re-irradiation using a three-dimensional conformal radiotherapy (3-D CRT) technique in patients with locally recurrent carcinoma of the nasopharynx. Four patients with locally recurrent nasopharyngeal cancer were retreated with a hyperfractionated schedule using a 3-D CRT technique. Re-irradiation was delivered in 1.1-1.2 Gy fractions twice per day (BID), with interfraction intervals of more than 6 hours. The total dose ranged from 59.4 to 69.2 Gy. A 3-D CRT technique with 5- or 6-field coplanar and/or non-coplanar beams were employed during the entire treatment procedure. All four patients achieved complete remission of locally recurrent lesions, with marked improvement of subjective symptoms, immediately after re-irradiation. All are alive and well without evidence of disease after limited follow-up periods, which range from 7 to 20 months. So far, there have been no radiation-induced neurologic complications. Four patients with locally recurrent carcinoma of the nasopharynx were successfully treated by hyperfractionated re-irradiation using a 3-D CRT technique. A relatively high re-irradiation dose of more than 60 Gy may be safely delivered with no serious acute or late radiation-induced complications in patients with local recurrences and who were initially treated with doses greater than 70 Gy.
评估三维适形放疗（3-D CRT）技术进行超分割再程放疗对局部复发鼻咽癌患者的疗效。4例局部复发鼻咽癌患者采用3-D CRT技术进行超分割方案再程放疗。再程放疗采用每次1.1 - 1.2 Gy，每天2次（BID），两次照射间隔超过6小时。总剂量范围为59.4至69.2 Gy。整个治疗过程采用5野或6野共面和/或非共面射束的3-D CRT技术。4例患者再程放疗后局部复发病灶均完全缓解，主观症状明显改善。在7至20个月的有限随访期后，所有患者均存活且状况良好，无疾病证据。迄今为止，未出现放射性神经并发症。4例局部复发鼻咽癌患者采用3-D CRT技术进行超分割再程放疗取得成功。对于局部复发且初始治疗剂量大于70 Gy的患者，可安全给予超过60 Gy的相对高再程放疗剂量，且无严重的急性或晚期放射性并发症。
