自我刺激以及向大鼠脑内局部注射6-羟基多巴胺：α-甲基对酪氨酸增强的行为抑郁效应

Self-stimulation and local injections of 6-hydroxydopamine into the rat brain: enhanced behavioral depressive effects of alpha-methylparatyrosine.

作者信息

Stinus L, Thierry A M, Cardo B

出版信息

Pharmacol Biochem Behav. 1975 Jan-Feb;3(1):19-23. doi: 10.1016/0091-3057(75)90075-1.

Abstract

The effects of intracerebral injections of 6-OHDA on self-stimulation were examined. Small amounts of 6-OHDA were injected either in the area ventralis tegmenti (AVT) or laterally in the pedonculus cerebellaris superior (PCS), then all rats were implanted in the AVT. In spite of marked depletion of brain catecholamines, self-stimulation learning was not altered by PCS 6-OHDA injections, whereas, AVT 6-OHDA injections produced a small perturbance. The administration of low doses of AMPT which had no observable effect in control rats, produced a severe depression of self-stimulation rates in 6-OHDA pretreated rats. The depressive effect of AMPT is always more important in rats injected with 6-OHDA in the AVT than those injected at the level of PCS. The respective role of noradrenergic and dopaminergic neurons in AVT self-stimulation are discussed.

摘要

研究了脑室内注射6-羟基多巴胺（6-OHDA）对自我刺激的影响。将少量6-OHDA注射到腹侧被盖区（AVT）或小脑上脚外侧（PCS），然后将所有大鼠植入AVT。尽管脑儿茶酚胺明显耗竭，但PCS注射6-OHDA并未改变自我刺激学习，而AVT注射6-OHDA则产生了轻微干扰。低剂量的对氯苯丙氨酸（AMPT）对对照大鼠无明显影响，但在6-OHDA预处理的大鼠中导致自我刺激率严重降低。在AVT注射6-OHDA的大鼠中，AMPT的抑制作用总是比在PCS水平注射的大鼠更显著。文中讨论了去甲肾上腺素能和多巴胺能神经元在AVT自我刺激中的各自作用。