6-甲氧基-1,2,3,4-四氢-α-咔啉对小鼠听源性和电惊厥发作的抗惊厥作用
Anticonvulsant effects of 6-methoxy-1, 2, 3, 4-tetrahydro-alpha-carboline on audiogenic and electroconvulsive seizures in mice.
作者信息
Buckholtz N S
出版信息
Pharmacol Biochem Behav. 1975 Jan-Feb;3(1):65-8. doi: 10.1016/0091-3057(75)90081-7.
6-Methoxy-1, 2, 3, 4, -tetrahydro-beta-carboline (6-MeO-THBC) was tested for anticonvulsant properties against audiogenic seizures in DBA/2J and primed C57BL/6J mice (i.e., mice given a prior auditory exposure) and aginast electroconvulsive seizures in DBA/2J mice. 6-MeO-THBC (100 mg/kg) was found to attenuate both types of behavioral seizures 2 hr after injection as compared to saline controls. In addition, 6-MeO-THBC increased whole brain serotonin and decreased whole brain 5-hydroxyindoleacetic acid 2 hr after injection. These results support previous reports which suggest a serotonergic involvement in behavioral seizures.
对6-甲氧基-1,2,3,4-四氢-β-咔啉（6-MeO-THBC）进行了测试，观察其对DBA/2J和致敏C57BL/6J小鼠（即事先接受过听觉暴露的小鼠）的听源性癫痫发作以及对DBA/2J小鼠电惊厥发作的抗惊厥特性。与生理盐水对照组相比，发现注射后2小时，6-MeO-THBC（100毫克/千克）可减轻两种类型的行为性癫痫发作。此外，注射后2小时，6-MeO-THBC可使全脑血清素增加，并使全脑5-羟吲哚乙酸减少。这些结果支持了先前的报告，这些报告表明血清素能参与行为性癫痫发作。
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