吡喹酮和阿苯达唑联合治疗实验性包虫病

Praziquantel and albendazole in the combined treatment of experimental hydatid disease.

作者信息

Moreno M J, Urrea-París M A, Casado N, Rodriguez-Caabeiro F

机构信息

Parasitology Laboratory, Faculty of Pharmacy, University of Alcalá, Madrid, Spain.

出版信息

Parasitol Res. 2001 Mar;87(3):235-8. doi: 10.1007/s004360000334.

DOI:10.1007/s004360000334

PMID:11293572

Abstract

The combination of praziquantel and albendazole (PZ + ABZ) used in the present study demonstrated an efficacy of 100% when used as chemoprophylactic treatment because no viable hydatid cysts developed after mice had been injected with protoscolices. However, when the PZ + ABZ combination was used for the treatment of 4-month secondary experimental hydatidosis, no significant difference was found between the control and treated mice, although severe damage to the cyst ultrastructure of the treated mice was observed.

摘要

本研究中使用的吡喹酮和阿苯达唑联合用药（PZ + ABZ）在用作化学预防治疗时显示出100%的疗效，因为在给小鼠注射原头节之后没有形成存活的包虫囊肿。然而，当PZ + ABZ联合用药用于治疗4个月的继发性实验性包虫病时，尽管观察到治疗组小鼠的囊肿超微结构受到严重破坏，但在对照组和治疗组小鼠之间未发现显著差异。