Pearson G, Robinson F, Beers Gibson T, Xu B E, Karandikar M, Berman K, Cobb M H
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Endocr Rev. 2001 Apr;22(2):153-83. doi: 10.1210/edrv.22.2.0428.
Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. MAP kinases lie in protein kinase cascades. This review discusses the regulation and functions of mammalian MAP kinases. Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted. Particular emphasis is on ERK1/2.
丝裂原活化蛋白（MAP）激酶是一类普遍存在的脯氨酸定向蛋白丝氨酸/苏氨酸激酶家族，它们参与信号转导途径，控制细胞内事件，包括对激素的急性反应和生物体的主要发育变化。MAP激酶存在于蛋白激酶级联反应中。本综述讨论了哺乳动物MAP激酶的调节和功能。着重介绍了影响MAP激酶功能的非酶机制以及基因敲除研究的结果。特别强调的是ERK1/2。
