衰老与退行性疾病中的线粒体DNA。

Mitochondrial DNA in aging and degenerative disease.

作者信息

Berdanier C D, Everts H B

机构信息

Department of Foods and Nutrition, University of Georgia, 30602, Athens, GA, USA.

出版信息

Mutat Res. 2001 Apr 18;475(1-2):169-83. doi: 10.1016/s0027-5107(01)00068-9.

DOI:10.1016/s0027-5107(01)00068-9

PMID:11295162

Abstract

The mitochondrial DNA encodes only a few gene products compared to the nuclear DNA. These products, however, play a decisive role in determining cell function. Should this DNA mutate spontaneously or be damaged by free radicals the functionality of the gene products will be compromised. A number of mitochondrial genetic diseases have been identified. Some of these are quite serious and involve the central nervous system as well as muscle, heart, liver and kidney. Aging has been characterized by a gradual increase in base deletions in this DNA. This increase in deletion mutation has been suggested to be the cumulative result of exposure to free radicals.

摘要

与核DNA相比，线粒体DNA仅编码少数几种基因产物。然而，这些产物在决定细胞功能方面起着决定性作用。如果这种DNA自发突变或被自由基破坏，基因产物的功能将受到损害。已经发现了许多线粒体遗传疾病。其中一些相当严重，涉及中枢神经系统以及肌肉、心脏、肝脏和肾脏。衰老的特征是这种DNA中碱基缺失逐渐增加。有人认为这种缺失突变的增加是接触自由基的累积结果。