Zhong J, Chen Z, Kwok E, Kennedy S
Department of Radiology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Magn Reson Imaging. 2001 Jan;19(1):33-9. doi: 10.1016/s0730-725x(01)00223-5.
Apparent molecular self-diffusion rates for (1)H intermolecular double-quantum coherences (iDQCs) were measured in solvents covering a wide range of intrinsic diffusion coefficients at 1.5, 9.4 and 14T, and water iDQC diffusion-weighted images were obtained at 1.5T in human brains and at 9.4T in rat brains. Conventional single quantum coherence (SQC) measurements were also made in the same samples. Experimental results indicate that iDQCs are approximately twice as sensitive to diffusion as SQC. A general theoretical expression was derived, and a model was proposed to explain the phenomenon. Potential applications in DWI and brain fMRI were also discussed.
在1.5T、9.4T和14T磁场下，测量了覆盖广泛固有扩散系数范围的溶剂中（1）H分子间双量子相干（iDQC）的表观分子自扩散率，并在1.5T磁场下获得了人脑的水iDQC扩散加权图像，在9.4T磁场下获得了大鼠脑的水iDQC扩散加权图像。还对相同样品进行了传统的单量子相干（SQC）测量。实验结果表明，iDQC对扩散的敏感度约为SQC的两倍。推导了一个通用的理论表达式，并提出了一个模型来解释该现象。还讨论了其在扩散加权成像（DWI）和脑功能磁共振成像（fMRI）中的潜在应用。
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