Ling Wen, Eliav Uzi, Navon Gil, Jerschow Alexej
Chemistry Department, New York University, New York, NY 10003, USA.
J Magn Reson. 2008 Sep;194(1):29-32. doi: 10.1016/j.jmr.2008.05.026. Epub 2008 Jun 4.
A number of contrast enhancement effects based on the use of intermolecular multiple-quantum coherences, or distant dipolar field effects are known. This phenomenon is characterized by the dependence on the mth power of the initial magnetization (where m is the coherence order used). In this paper, we describe the contrast enhancement based on chemical exchange saturation transfer and NOE, which is achieved by the use of intermolecular double-quantum coherences (iDQC). The method was validated using clinically relevant systems based on glycosaminoglycans and a sample of cartilage tissue, showing that the CEST contrast, as well as, NOE are enhanced by iDQC.
基于分子间多量子相干或远距离偶极场效应的多种对比增强效应是已知的。这种现象的特征是依赖于初始磁化强度的m次方(其中m是所使用的相干阶数)。在本文中,我们描述了基于化学交换饱和转移和NOE的对比增强,这是通过使用分子间双量子相干(iDQC)实现的。该方法使用基于糖胺聚糖的临床相关系统和软骨组织样本进行了验证,结果表明CEST对比以及NOE通过iDQC得到了增强。