细菌化学感受器中的跨膜信号传导。
Transmembrane signaling in bacterial chemoreceptors.
作者信息
Falke J J, Hazelbauer G L
机构信息
Department of Chemistry and Biochemistry, University of Colorado, 80309-0215, Boulder, CO, USA.
出版信息
Trends Biochem Sci. 2001 Apr;26(4):257-65. doi: 10.1016/s0968-0004(00)01770-9.
Abstract
Bacterial chemoreceptors mediate chemotaxis by recognizing specific chemicals and regulating a noncovalently associated histidine kinase. Ligand binding to the external domain of the membrane-spanning receptor generates a transmembrane signal that modulates kinase activity inside the cell. This transmembrane signaling is being investigated by novel strategies, which have revealed a remarkably subtle conformational signal carried by a signaling helix that spans the entire length of the >350-A-long receptor. Multiple, independent lines of evidence indicate that, in the periplasmic and transmembrane domains, conformational signaling is a piston-type sliding of the signaling helix towards the cytoplasm.
摘要
细菌化学感受器通过识别特定化学物质并调节非共价结合的组氨酸激酶来介导趋化作用。配体与跨膜受体的外部结构域结合会产生一个跨膜信号，该信号调节细胞内的激酶活性。目前正在通过新策略研究这种跨膜信号传导，这些策略揭示了一个由跨越长度超过350埃的受体全长的信号螺旋携带的非常微妙的构象信号。多条独立的证据表明，在周质和跨膜结构域中，构象信号传导是信号螺旋向细胞质的活塞式滑动。
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