Gedde-Dahl T W, Jeremic M, Weisert O
Scand J Clin Lab Invest. 1975 Jan;35(1):25-30.
Factor V (proaccelerin) concentration was measured in the plasma of 1016 regular and controlled blood donors. Age had a highly significant effect on factor V concentration. The median rose from 99 per cent at the age of 20 to 123 at the age of 60 years. Minor effects of sex and ABO blood groups were suggested. Interactions between these factors were found negligible. Accuracy and precision of the assay method and the use of percentiles in the laboratory reports are discussed. The results may support the hypothesis of relation between high concentration of coagulation factor V and predisposition to thrombosis.
在1016名定期献血且接受过体检的献血者的血浆中测量了凝血因子V（前加速素）的浓度。年龄对凝血因子V浓度有极显著影响。中位数从20岁时的99%升至60岁时的123%。研究表明性别和ABO血型有轻微影响。发现这些因素之间的相互作用可忽略不计。讨论了检测方法的准确性和精密度以及实验室报告中百分位数的使用。这些结果可能支持凝血因子V浓度高与血栓形成易感性之间存在关联的假说。
