胆碱酯酶中酰基口袋结构的新数据。 - Suppr

New data on the structure of the acyl pocket in cholinesterases.

作者信息

Moralev S N

机构信息

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Morisa Toreza 44, St. Petersburg, 194223 Russia.

出版信息

Dokl Biochem. 2000 Nov-Dec;375:215-7. doi: 10.1023/a:1026663621004.

DOI:10.1023/a:1026663621004

PMID:11296473

Abstract

摘要

相似文献

New data on the structure of the acyl pocket in cholinesterases.胆碱酯酶中酰基口袋结构的新数据。

Dokl Biochem. 2000 Nov-Dec;375:215-7. doi: 10.1023/a:1026663621004.

Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors.用间隔基修饰的双价喹唑啉亚胺探测胆碱酯酶的中沟，得到高活性和选择性的丁酰胆碱酯酶抑制剂。

Bioorg Med Chem. 2011 Feb 1;19(3):1222-35. doi: 10.1016/j.bmc.2010.12.034. Epub 2010 Dec 21.

Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors.胆碱酯酶分子中的三个不同结构域赋予了对乙酰胆碱酯酶和丁酰胆碱酯酶抑制剂的选择性。

Biochemistry. 1993 Nov 16;32(45):12074-84. doi: 10.1021/bi00096a018.

Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases.石杉碱甲与胆碱酯酶结合所涉及的氨基酸残基的鉴定。

Protein Sci. 1994 Oct;3(10):1770-8. doi: 10.1002/pro.5560031017.

Cryo-electron microscopy of cholinesterases, present and future.胆碱酯酶的冷冻电子显微镜：现在与未来。

J Neurochem. 2021 Sep;158(6):1236-1243. doi: 10.1111/jnc.15245. Epub 2020 Dec 10.

Inhibition of two different cholinesterases by tacrine.他克林对两种不同胆碱酯酶的抑制作用。

Chem Biol Interact. 2006 Aug 25;162(2):165-71. doi: 10.1016/j.cbi.2006.06.002. Epub 2006 Jun 17.

[Sensitivity of cholinesterases from various sources to organophosphate inhibitors with S-alkyl radicals of various lengths].

Zh Evol Biokhim Fiziol. 2003 Sep-Oct;39(5):405-9.

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.人源乙酰胆碱酯酶和丁酰胆碱酯酶与 huprine W 和他克林复合物的晶体结构：针对乙酰胆碱酯酶和丁酰胆碱酯酶的阿尔茨海默病治疗药物的特异性要素。

Biochem J. 2013 Aug 1;453(3):393-9. doi: 10.1042/BJ20130013.

Specificity and orientation of trigonal carboxyl esters and tetrahedral alkylphosphonyl esters in cholinesterases.胆碱酯酶中三角羧基酯和四面体烷基膦酸酯的特异性与取向

Biochemistry. 1995 Sep 12;34(36):11528-36. doi: 10.1021/bi00036a028.

Polymorphism of pseudocholinesterase in Torpedo marmorata tissues: comparative study of the catalytic and molecular properties of this enzyme with acetylcholinesterase.斑纹电鳐组织中假性胆碱酯酶的多态性：该酶与乙酰胆碱酯酶催化及分子特性的比较研究

J Neurochem. 1985 Feb;44(2):580-92. doi: 10.1111/j.1471-4159.1985.tb05452.x.

本文引用的文献

[Comparative sensitivity of different Cholinesterases of different origin to its inhibitors].[不同来源的不同胆碱酯酶对其抑制剂的比较敏感性]

Zh Evol Biokhim Fiziol. 2004 Jan-Feb;40(1):3-15.

[The use of the multidimensional statistic analysis for investigation of anticholinesterase activity of organophosphorus inhibitors depending on their structure].[利用多维统计分析研究基于结构的有机磷抑制剂的抗胆碱酯酶活性]

Zh Evol Biokhim Fiziol. 1997 May-Jun;33(3):302-7.

The architecture of human acetylcholinesterase active center probed by interactions with selected organophosphate inhibitors.通过与选定有机磷酸酯抑制剂的相互作用探究人乙酰胆碱酯酶活性中心的结构

J Biol Chem. 1996 May 17;271(20):11953-62. doi: 10.1074/jbc.271.20.11953.

Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket.人类乙酰胆碱酯酶底物特异性活性中心决定因素的剖析。构成阴离子位点、疏水位点和酰基口袋的残基鉴定。

J Biol Chem. 1993 Aug 15;268(23):17083-95.

Biochemistry. 1993 Nov 16;32(45):12074-84. doi: 10.1021/bi00096a018.

Specificity and orientation of trigonal carboxyl esters and tetrahedral alkylphosphonyl esters in cholinesterases.胆碱酯酶中三角羧基酯和四面体烷基膦酸酯的特异性与取向

Biochemistry. 1995 Sep 12;34(36):11528-36. doi: 10.1021/bi00036a028.

Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein.加州电鳐乙酰胆碱酯酶的原子结构：一种典型的乙酰胆碱结合蛋白。

Science. 1991 Aug 23;253(5022):872-9. doi: 10.1126/science.1678899.

Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis.乙酰胆碱酯酶向丁酰胆碱酯酶的转化：建模与诱变

Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10827-31. doi: 10.1073/pnas.89.22.10827.

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New data on the structure of the acyl pocket in cholinesterases.

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