Lagodych T S
A. A. Bogomoletz National Medical University, Kiev.
Fiziol Zh (1994). 2001;47(1):34-8.
On the isolated guinea--pig heart perfused under Langendorff preparation influence of the NO was studied. Donators of NO were nitroglycerinum and sodium nitroprusside. The myocardium contractive activity indeces and the coronary flow were studied before and after introduction of the guanilatcyclase blockade by methylene blue. The received results show that after introduction of nitroglycerinum and sodium nitroprusside myocardium contractive activity indeces decrease, and the coronary flow increases. After introduction of methylene blue myocardium contractive activity indeces almost do not change--that confirms the guanilatcyclase mechanism of NO effect.
在Langendorff离体豚鼠心脏灌注模型上研究了一氧化氮（NO）的作用。NO的供体为硝酸甘油和硝普钠。在通过亚甲蓝阻断鸟苷酸环化酶前后，研究了心肌收缩活性指标和冠脉流量。结果显示，给予硝酸甘油和硝普钠后，心肌收缩活性指标降低，冠脉流量增加。给予亚甲蓝后，心肌收缩活性指标几乎无变化，这证实了NO作用的鸟苷酸环化酶机制。
