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[Elevated level of TGF-alpha in the mucosa of small intestine of the rat following massive small bowel resection].

作者信息

Fil'chenkov O O

机构信息

R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Science of Ukraine, Kiev.

出版信息

Fiziol Zh (1994). 2001;47(1):61-7.

PMID:11296558
Abstract

This study was performed to determine the changes in TGF-alpha production during compensatory regeneration of small intestine. For this purpose rats underwent either 70% small bowel resection or sham operation. Levels of TGF-alpha production were evaluated by radioreceptor assay and Western blotting. When compared with sham operation, small bowel resection resulted in threefold increase in the production of TGF-alpha at postoperative day 3. Possible mechanisms of TGF-alpha involvement in intestinal adaptation following massive small bowel resection are discussed.

摘要

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