Madden J W, Carlson E C, Hines J
Surg Gynecol Obstet. 1975 Apr;140(4):509-16.
Biopsies of fibrotic interosseous muscles were obtained from three patients with ischemic contracture of the intrinsic muscles of the hand. Control biopsies were taken from normal contralateral interossei and from normal interossei crushed three weeks earlier. Examination of the specimens from the affected muscles under the electron microscope demonstrated large numbers of modified fibroblasts with ultrastructural features of both fibroblasts and smooth muscle cells. The atypical fibroblasts observed resembled myofibroblasts seen in contracting wounds, Dupuytren's contracture, stenosing tenosynovitis, and idiopathic carpel tunnel syndrome. Biopsies from normal muscle and crushed normal muscle contained normal fibroblasts and smooth muscle cells but no modified fibroblasts. Active contraction of modified fibroblasts could be responsible for progressive muscle shortening seen in intrinsic contracture.
从三名手部固有肌缺血性挛缩患者身上获取了纤维化骨间肌的活检样本。对照活检样本取自对侧正常骨间肌以及三周前挤压过的正常骨间肌。在电子显微镜下检查受影响肌肉的标本发现，有大量具有成纤维细胞和平滑肌细胞超微结构特征的改良成纤维细胞。观察到的非典型成纤维细胞类似于在收缩性伤口、掌腱膜挛缩症、狭窄性腱鞘炎和特发性腕管综合征中所见的肌成纤维细胞。正常肌肉和挤压过的正常肌肉的活检样本中含有正常的成纤维细胞和平滑肌细胞，但没有改良成纤维细胞。改良成纤维细胞的活跃收缩可能是固有肌挛缩中所见进行性肌肉缩短的原因。
