From Attebring M, Herlitz J, Berndt A K, Karlsson T, Hjalmarson A
Division of Cardiology, Sahlgrenska University Hospital, Göteborg, Sweden.
J Intern Med. 2001 Feb;249(2):145-51. doi: 10.1046/j.1365-2796.2001.00770.x.
To validate self-report about smoking cessation with biochemical markers of smoking activity amongst patients with ischaemic heart disease.
Outpatients at the Division of Cardiology, 75 years of age or younger, who had been Hospitalized at Sahlgrenska University Hospital in Göteborg due to an ischaemic event and who consecutively participated in a nurse-monitored routine care programme for secondary prevention, from 6 February 1997 to 5 February 1998. Data concerning smoking habits were collected through interviews. Two chemical markers, cotinine in plasma and carbon monoxide (CO) in expired air, validated self-reports concerning smoking cessation.
260 former smokers were validated. In the vast majority of the study population, the anamnestic information concurred with the chemical marker. However, 17 patients had chemical markers that contradicted their self-report with raised CO (n = 6) and/or raised cotinine levels (n = 13) without alternative nicotine delivery.
Most patients with coronary artery disease relating information concerning cessation of smoking are truthful. A few patients, however, seem to conceal their smoking. Testing by chemical markers may be questionable for ordinary care but should, however, be included in studies concerning the association between smoking and health.
在缺血性心脏病患者中，用吸烟活动的生化标志物验证戒烟的自我报告。
1997年2月6日至1998年2月5日期间，哥德堡萨尔格伦斯卡大学医院因缺血性事件住院、年龄在75岁及以下、在心脏病科门诊且连续参加护士监测的二级预防常规护理项目的患者。通过访谈收集吸烟习惯的数据。两种化学标志物，即血浆中的可替宁和呼出气体中的一氧化碳（CO），验证了有关戒烟的自我报告。
260名既往吸烟者得到验证。在绝大多数研究人群中，既往史信息与化学标志物一致。然而，17名患者的化学标志物与他们的自我报告相矛盾，即CO升高（n = 6）和/或可替宁水平升高（n = 13），且无其他尼古丁摄入途径。
大多数报告戒烟情况的冠心病患者所言属实。然而，有少数患者似乎隐瞒了他们的吸烟情况。对于常规护理而言，用化学标志物进行检测可能存在问题，但在有关吸烟与健康关联的研究中应予以纳入。
