Jarvis J Q, Morey P R
University of Nevada School of Medicine, Reno, USA.
Appl Occup Environ Hyg. 2001 Mar;16(3):380-8. doi: 10.1080/10473220117482.
An outbreak of allergic respiratory disease occurred in a new building that was characterized from initial occupancy by the presence of extensive visible mold (especially Aspergillus versicolor) on interior surfaces. Epidemiological study of the occupants of both the affected building and a comparison neighboring structure indicated high rates of respiratory and other symptoms among persons working in the affected building. Subsequent clinical evaluations of some persons occupying the building for up to five years identified several cases of building-related allergic respiratory disease, including asthma and hypersensitivity pneumonitis. Based on these findings, the building was evacuated before remediation began. The mycological goal of the three-year building restoration project was to reduce concentration of non-phylloplane fungi such as A. versicolor to the lowest feasible level. All visibly colonized materials in the building were discarded and all fine dust on interior surfaces was removed by vacuuming and/or damp wiping. A medical surveillance program utilizing serial self-reported questionnaires and readily available clinical evaluations was designed to monitor the health of building occupants after re-entry. Symptom rates just prior to building reentry were substantially lower than those found before evacuation and have remained unchanged after re-occupancy was completed. No new or recrudescent cases of illness are known to have occurred after building re-entry.
一座新建筑内爆发了过敏性呼吸道疾病，其特点是自最初入住起，内表面就出现大量可见霉菌（尤其是杂色曲霉）。对受影响建筑的居住者以及邻近对照建筑的居住者进行的流行病学研究表明，在受影响建筑中工作的人员出现呼吸道及其他症状的比例很高。随后，对在该建筑中居住长达五年的部分人员进行的临床评估发现了几例与建筑相关的过敏性呼吸道疾病，包括哮喘和过敏性肺炎。基于这些发现，在修复工作开始前，该建筑内人员被疏散。为期三年的建筑修复项目的真菌学目标是将杂色曲霉等非叶栖真菌的浓度降低到可行的最低水平。建筑内所有可见被霉菌定殖的材料均被丢弃，内表面的所有细尘通过吸尘和/或湿擦拭清除。设计了一个医疗监测项目，利用系列自我报告问卷和易于进行的临床评估来监测建筑重新入住后居住者的健康状况。在建筑重新入住前的症状发生率大幅低于疏散前的水平，并且在重新入住完成后保持不变。据了解，建筑重新入住后未出现新的或复发的病例。
