土耳其南部患微小病变病及其他类型肾病综合征儿童的人类白细胞抗原

HLAs in children with minimal change disease and other types of nephrotic syndrome in the southern part of Turkey.

作者信息

Karabay-Bayazit A, Noyan A, Bayazit Y, Ozel A, Anarat A

机构信息

Department of Pediatrics, Cukurova University Faculty of Medicine, Adana, Turkey.

出版信息

Turk J Pediatr. 2001 Jan-Mar;43(1):24-8.

PMID:11297154

Abstract

The aim of this study was to investigate the human leukocyte antigen (HLA) profile of children with nephrotic syndrome in the southern part of Turkey. Seventy-eight children with nephrotic syndrome were studied for the frequency of class I and class II human leukocyte antigens. Forty-seven of them were steroid sensitive nephrotic syndrome (minimal change disease-MCD) and 31 were other types of nephrotic syndrome. The results were compared with 133 healthy subjects for HLA groups. HLA B13, Cw5, Cw7, DR4, DR7, DRw10, Drw15(2) and DQ2 in the MCD group and HLA A31, B8, B13, B17, Cw2, Cw6, Cw7, DRw10 and DRw12 in the non-MCD group were found significantly increased when compared to healthy controls. MCD patients with frequent relapses had higher frequencies of both Cw6 and DR1 (p < 0.005) and MCD patients with infrequent relapses had a higher frequency of Cw7 (p < 0.05). In conclusion, HLA groups may help in the early diagnosis of these variants.

摘要

本研究的目的是调查土耳其南部肾病综合征患儿的人类白细胞抗原（HLA）谱。对78例肾病综合征患儿进行了I类和II类人类白细胞抗原频率的研究。其中47例为类固醇敏感型肾病综合征（微小病变病-MCD），31例为其他类型的肾病综合征。将结果与133名健康受试者的HLA组进行比较。与健康对照组相比，MCD组中的HLA B13、Cw5、Cw7、DR4、DR7、DRw10、Drw15(2)和DQ2以及非MCD组中的HLA A31、B8、B13、B17、Cw2、Cw6、Cw7、DRw10和DRw12显著增加。频繁复发的MCD患者Cw6和DR1的频率均较高（p<0.005），复发不频繁的MCD患者Cw7的频率较高（p<0.05）。总之，HLA组可能有助于这些变异型的早期诊断。