Panasci L, Paiement J P, Christodoulopoulos G, Belenkov A, Malapetsa A, Aloyz R
Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada.
Clin Cancer Res. 2001 Mar;7(3):454-61.
Various mechanisms have been implicated in nitrogen mustard drug resistance. The role of these mechanisms in the development of chlorambucil drug resistance in chronic lymphocytic leukemia (CLL) is discussed. We review these mechanisms with emphasis on the emerging role of DNA repair, and specifically, recombinational repair. Inhibition of these repair processes may lead to new therapies, not only in CLL, but in other malignancies as well.
多种机制与氮芥耐药性有关。本文讨论了这些机制在慢性淋巴细胞白血病（CLL）苯丁酸氮芥耐药性发展中的作用。我们回顾了这些机制，重点关注DNA修复，特别是重组修复的新作用。抑制这些修复过程可能会带来新的治疗方法，不仅适用于CLL，也适用于其他恶性肿瘤。
