含脱氢丙氨酸和脱氢苯丙氨酸的四肽对硝基苯苯胺的合成及其对组织蛋白酶C活性的影响。
Synthesis of tetrapeptide p-nitrophenylanilides containing dehydroalanine and dehydrophenylalanine and their influence on cathepsin C activity.
作者信息
Makowski M, Pawelczak M, Latajka R, Nowak K, Kafarski P
机构信息
Institute of Chemistry, University of Opole, Oleska, Poland.
出版信息
J Pept Sci. 2001 Mar;7(3):141-5. doi: 10.1002/psc.307.
DOI:10.1002/psc.307
PMID:11297349
Abstract
Three dehydrotetrapeptides of rationally varying structure were prepared and tested as affectors of cathepsin C. These compounds appeared to be substrates of the enzyme, being equipotent with their classical counterparts. Thus, replacement of amino acid in a short peptide by corresponding dehydroamino acid does not prevent cathepsin C in recognizing dehydropeptide as its substrate.
摘要
制备了三种结构合理变化的脱氢四肽，并将其作为组织蛋白酶C的效应物进行测试。这些化合物似乎是该酶的底物，与它们的经典对应物具有同等效力。因此，在短肽中用相应的脱氢氨基酸取代氨基酸并不妨碍组织蛋白酶C将脱氢肽识别为其底物。
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