Takahashi T, Tsukahara Y
Tohoku J Exp Med. 1975 Jan;115(1):1-10. doi: 10.1620/tjem.115.1.
The generalized paroxysmal discharges (GPDs) induced by the visuo-sensory and oculomotor activations in a total of 30 patients were investigated. The patients consisted of 27 epileptics and 3 with sequelae of head trauma; all of them showed photoconvulsive response. The visuo-sensory activation with red-flicker of 15 cycles/sec or with visual stimuli containing patterns, "pattern," was carried out under the constant condition of 20 cd/m-2. In 22 cases (73%), G-type (simultaneous occurrence of GPD over all the areas) was induced by red-flicker, while in 28 cases (93%) P-type (GPD was preceded by posterior spikes) was induced by "pattern." With the oculomotor activation, paroxysmal discharges were induced in 11 cases of photogenic epilepsy; 10 cases (91%) were of A-type (GPD was preceded by anterior spikes), and one case (9%) showed focal spikes over the right frontal area. In 21 cases (70%), the type of GPD changed from G-type to P-type as the red-flicker activation was replaced by the "pattern" activation. Further, in seven (33%) out of the 21 cases it changed from P-type to A-type as the activation with "pattern" was replaced by the oculomotor activation. It was suggested that the non-specific thalamo-cortical system, the visual cortex, and the frontal eye field are chiefly concerned with the occurrences of G-type, P-type, and A-type, respectively, when such stimuli as described above are given independently.
对30例患者在视觉感觉和动眼神经激活下诱发的全身性阵发放电（GPDs）进行了研究。患者包括27例癫痫患者和3例头部外伤后遗症患者；他们均表现出光惊厥反应。在20 cd/m²的恒定条件下，采用15次/秒的红色闪烁或包含图案“pattern”的视觉刺激进行视觉感觉激活。在22例（73%）中，红色闪烁诱发了G型（所有区域同时出现GPD），而在28例（93%）中，“pattern”诱发了P型（GPD之前有后放电）。在动眼神经激活时，11例光敏性癫痫患者诱发了阵发放电；10例（91%）为A型（GPD之前有前放电），1例（9%）在右侧额叶区域出现局灶性放电。在21例（70%）中，随着红色闪烁激活被“pattern”激活取代，GPD的类型从G型变为P型。此外，在这21例中的7例（33%）中，随着“pattern”激活被动眼神经激活取代，它从P型变为A型。结果表明，当单独给予上述刺激时，非特异性丘脑 - 皮质系统、视觉皮层和额叶眼区分别主要与G型、P型和A型的发生有关。
