Bouma B N, Marx P F, Mosnier L O, Meijers J C
Thrombosis and Hemostasis Laboratory, Department of Haematology, University Medical Center, Utrecht, The Netherlands.
Thromb Res. 2001 Mar 1;101(5):329-54. doi: 10.1016/s0049-3848(00)00411-4.
Recently, a new inhibitor of fibrinolysis was described. This inhibitor downregulated fibrinolysis after it was activated by thrombin, and was therefore named TAFI (thrombin-activatable fibrinolysis inhibitor; EC 3.4.17.20). TAFI turned out to be identical to previously described proteins, procarboxypeptidase U, procarboxypeptidase R, and plasma procarboxypeptidase B. In this overview, the protein will be referred to as TAFI. TAFI is a procarboxypeptidase and a member of the family of metallocarboxypeptidases. These enzymes are circulating in plasma and are present in several tissues such as pancreas. In this review, we will describe the properties of basic carboxypeptidases with the emphasis on the role of TAFI in coagulation and fibrinolysis. It cannot be ruled out, however, that TAFI has other, yet undefined, functions in biology.
最近，一种新的纤溶酶抑制剂被发现。该抑制剂在被凝血酶激活后下调纤溶作用，因此被命名为TAFI（凝血酶激活的纤溶抑制剂；EC 3.4.17.20）。结果发现TAFI与先前描述的蛋白质、羧肽酶原U、羧肽酶原R和血浆羧肽酶原B相同。在本综述中，该蛋白质将被称为TAFI。TAFI是一种羧肽酶原，属于金属羧肽酶家族。这些酶在血浆中循环，并存在于胰腺等多种组织中。在这篇综述中，我们将描述碱性羧肽酶的特性，重点是TAFI在凝血和纤溶中的作用。然而，不能排除TAFI在生物学中还有其他尚未明确的功能。
