Buist D S, LaCroix A Z, Barlow W E, White E, Weiss N S
Center for Health Studies, Group Health Cooperative of Puget Sound, Seattle, WA 98101, USA.
J Clin Epidemiol. 2001 Apr;54(4):417-22. doi: 10.1016/s0895-4356(00)00301-2.
Two recent studies have shown a woman's bone mineral density (BMD) (a composite measure of exposure to many different factors throughout one's lifetime) predicts breast cancer. In a prospective cohort study, we examined whether hip BMD was associated with breast cancer risk among 8203 postmenopausal women. During an average follow-up of 3.7 years, 131 incident breast cancer cases (102 invasive) were identified. Cox proportional hazards models were used to obtain estimates of the relative risk of breast cancer. Our results demonstrate an increase in breast cancer risk among women with higher BMD. Independent of age, geographic area, and body mass index, relative to the lowest BMD quartile the risk of breast cancer (95% confidence interval) by increasing quartile was 1.9 (1.1, 3.2), 1.5 (0.8, 2.6), and 1.5 (0.8, 2.7), respectively. An examination of other factors important in determining BMD may help explain the positive association between BMD and breast cancer.
最近的两项研究表明，女性的骨矿物质密度（BMD）（一种衡量一生接触多种不同因素的综合指标）可预测乳腺癌。在一项前瞻性队列研究中，我们调查了8203名绝经后女性的髋部骨密度与乳腺癌风险之间是否存在关联。在平均3.7年的随访期间，共确诊了131例新发乳腺癌病例（102例浸润性病例）。采用Cox比例风险模型来估计乳腺癌的相对风险。我们的研究结果表明，骨密度较高的女性患乳腺癌的风险增加。独立于年龄、地理区域和体重指数，相对于最低骨密度四分位数，随着骨密度四分位数的增加，乳腺癌风险（95%置信区间）分别为1.9（1.1, 3.2）、1.5（0.8, 2.6）和1.5（0.8, 2.7）。对其他影响骨密度的重要因素进行研究，可能有助于解释骨密度与乳腺癌之间的正相关关系。
