Cagnacci A, Arangino S, Renzi A, Paoletti A M, Melis G B, Cagnacci P, Volpe A
Institute of Obstetrics and Gynaecology of Modena, Modena, Italy.
Clin Endocrinol (Oxf). 2001 Mar;54(3):339-46. doi: 10.1046/j.1365-2265.2001.01232.x.
The effect of melatonin on human carbohydrate metabolism is not yet clear. We investigated whether melatonin influences glucose tolerance and insulin sensitivity in aged women.
Twenty-two postmenopausal women of whom 14 were on hormone replacement therapy.
After an overnight fast, at 0800 hours on two nonconsecutive days, placebo or melatonin (1 mg) were administered randomly and in a double blind fashion. Forty-five minutes later, an oral glucose tolerance test (75 g; OGTT) was performed in 13 women. In another nine women insulin-dependent (Si) and -independent (Sg) glucose utilization was tested by a frequently sampled intravenous glucose tolerance test (FSIGT).
Areas under the response curve to OGTT (AUC) for glucose (1420 +/- 59 vs. 1250 +/- 55 mmol x min/l; P < 0.01), and C-peptide (42,0980 +/- 45,320 vs. 33,528 +/- 15,779 pmol x min/l; P < 0.02) were higher following melatonin than placebo, while Si values were lower (2.6 +/- 0.28 units vs. 3.49 +/- 0.4 units; P < 0.03). Si modifications induced by melatonin were inversely related to Si values of the placebo day (r(2) = 0.538; P < 0.025).
The present results indicate that in aged women administration of 1 mg of melatonin reduces glucose tolerance and insulin sensitivity. The present data may have both physiological and clinical implications.
褪黑素对人体碳水化合物代谢的影响尚不清楚。我们研究了褪黑素是否会影响老年女性的葡萄糖耐量和胰岛素敏感性。
22名绝经后女性，其中14名接受激素替代疗法。
在禁食过夜后，于两个非连续日的08:00随机、双盲给予安慰剂或褪黑素（1毫克）。45分钟后，13名女性进行了口服葡萄糖耐量试验（75克；OGTT）。另外9名女性通过频繁采样静脉葡萄糖耐量试验（FSIGT）检测胰岛素依赖性（Si）和非胰岛素依赖性（Sg）葡萄糖利用情况。
褪黑素组葡萄糖的OGTT反应曲线下面积（AUC）（1420±59 vs. 1250±55 mmol·min/l；P<0.01）和C肽（420980±45320 vs. 33528±15779 pmol·min/l；P<0.02）高于安慰剂组，而Si值较低（2.6±0.28单位 vs. 3.49±0.4单位；P<0.03）。褪黑素引起的Si变化与安慰剂日的Si值呈负相关（r² = 0.538；P<0.025）。
目前的结果表明，老年女性服用1毫克褪黑素会降低葡萄糖耐量和胰岛素敏感性。目前的数据可能具有生理和临床意义。
