Ota T, Hata Y, Tanikawa A, Amagai M, Tanaka M, Nishikawa T
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Clin Exp Dermatol. 2001 Mar;26(2):179-81. doi: 10.1046/j.1365-2230.2001.00790.x.
Eosinophilic pustular folliculitis (EPF) is characterized by erythematous patches of large follicular papules and pustules involving mainly the face. Although various treatments have been attempted for EPF, including systemic and topical steroid, diaphenylsulphone, colchicine, minocycline as well as UVB phototherapy, there is no consensus on the first choice of treatment. We report a typical case and summarize 25 patients with EPF treated in our hospital between 1978 and 1998. Indomethacin was most frequently used (12/25) and showed clinical improvement in the majority of the cases (11/12). The effect of indomethacin was usually observed within 1--2 weeks after initiation of treatment. Decrease of peripheral blood eosinophils accompanied the clinical improvement. Thus, indomethacin should be considered as a first choice of treatment for EPF.
嗜酸性脓疱性毛囊炎（EPF）的特征是主要累及面部的大毛囊丘疹和脓疱的红斑性斑块。尽管针对EPF尝试了各种治疗方法，包括全身和局部使用类固醇、二苯砜、秋水仙碱、米诺环素以及紫外线B光疗，但对于首选治疗方法尚无共识。我们报告了1例典型病例，并总结了1978年至1998年间在我院接受治疗的25例EPF患者。消炎痛使用最为频繁（12/25），大多数病例（11/12）临床症状得到改善。消炎痛的效果通常在开始治疗后1 - 2周内显现。随着临床症状改善，外周血嗜酸性粒细胞减少。因此，消炎痛应被视为EPF的首选治疗方法。
