Furuya A, Kume M, Kashimoto S, Kumazawa T
Department of Anaesthesiology, Yamanashi Medical University, Shimokato 1110, Tamaho-cho, Nakakoma-gun, Yamanashi, Japan.
Eur J Anaesthesiol. 2001 Mar;18(3):184-8. doi: 10.1046/j.0265-0215.2000.00832.x.
Although there is concern that cibenzoline, an antidysrhythmic drug for the treatment of ventricular and supraventricular dysrhythmias, may be associated with dose-dependent inhibition of myocardial contractility there are few reports about the relationship between myocardial metabolism and cardiac function when it is used. The present study was designed to investigate the effects of cibenzoline on cardiac function and metabolism. The effects of cibenzoline on cardiac function and myocardial metabolism were assessed in the isolated rat heart-lung preparation.
Thirty-two male Wistar-ST rats were divided into four groups: control, and those to receive cibenzoline, either 300, 900 or 3000 ng mL(-1). The cibenzoline was administered into the perfusate 5 min after the start of perfusion. Heart rates in the 3000 ng mL(-1) group were significantly lower than those in the control group. Cardiac output in the 3000 ng mL(-1) group at 15 and 30 min was significantly lower than in the control group. In all groups, values for %LV dP/dt max (the ratio of values at each time to those at 5 min) at 20, 25, 30 min were significantly higher than at 5 min. Myocardial adenosine triphosphate concentration in the 3000 ng mL(-1) group was significantly lower than in controls. There was no difference between groups in the lactate/pyruvate ratio.
The therapeutic range of cibenzoline has few effects on cardiac function and metabolism, although concentrations 10 times greater may cause a deterioration in myocardial metabolism.
尽管有人担心用于治疗室性和室上性心律失常的抗心律失常药物西苯唑啉可能与剂量依赖性心肌收缩抑制有关，但关于其使用时心肌代谢与心脏功能之间关系的报道却很少。本研究旨在探讨西苯唑啉对心脏功能和代谢的影响。在离体大鼠心肺标本中评估西苯唑啉对心脏功能和心肌代谢的影响。
将32只雄性Wistar-ST大鼠分为四组：对照组，以及分别接受300、900或3000 ng/mL西苯唑啉的组。在灌注开始5分钟后将西苯唑啉注入灌注液中。3000 ng/mL组的心率显著低于对照组。3000 ng/mL组在15分钟和30分钟时的心输出量显著低于对照组。在所有组中，20、25、30分钟时的%左心室dp/dt max（各时间点的值与5分钟时的值之比）均显著高于5分钟时。3000 ng/mL组的心肌三磷酸腺苷浓度显著低于对照组。各组之间乳酸/丙酮酸比值无差异。
西苯唑啉的治疗剂量对心脏功能和代谢影响很小，尽管浓度高出10倍可能会导致心肌代谢恶化。
