层粘连蛋白在具有不同转移潜能的转移性黑色素瘤细胞系中的表达
Expression of laminin in metastatic melanoma cell lines with different metastatic potential.
作者信息
Chen H B, Chen L, Zhung J K, Chow V W, Wu B Q, Wang Z H, Cheng S B, Chew E C
机构信息
Department of Histology and Embryology, Shantou Medical College, Shantou, China.
出版信息
Anticancer Res. 2001 Jan-Feb;21(1A):505-8.
Cancer metastasis is a complex multi-step process in which tumor cells leave the primary site and develop a secondary tumor in distant organs. Laminin plays an important role in this process. The expression of laminin in four melanoma cell lines with different metastatic potentials was investigated by immunohistochemistry, immunogold electron microscopy and Western blotting. Our results showed that the expression of endogenous laminin and the percentage of the positive cells are higher with increased metastatic potentials. It is, thus, suggested that endogenous laminin may contribute to the different metastatic properties in the melanoma cell line.
癌症转移是一个复杂的多步骤过程，在此过程中肿瘤细胞离开原发部位并在远处器官形成继发性肿瘤。层粘连蛋白在这一过程中发挥着重要作用。通过免疫组织化学、免疫金电子显微镜和蛋白质印迹法研究了层粘连蛋白在四种具有不同转移潜能的黑色素瘤细胞系中的表达情况。我们的结果表明，随着转移潜能的增加，内源性层粘连蛋白的表达及阳性细胞百分比更高。因此，提示内源性层粘连蛋白可能促成了黑色素瘤细胞系中不同的转移特性。
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