Mayerhofer K, Bodner K, Saletu B, Bodner-Adler B, Anderer P, Hefler L, Schindl M, Kaider A, Leodolter S, Kainz C
Department of Gynecology & Obstetrics, University of Vienna Medical School, A-1090 Vienna, Wahringer Gurtel 18-20, Austria.
Anticancer Res. 2001 Jan-Feb;21(1B):803-8.
The objective of this study was to evaluate possible effects of a paclitaxel containing chemotherapy, on the central nervous system (CNS) in women with ovarian cancer.
Twenty-eight women with histologically documented epithelial ovarian carcinoma and treated with a combination chemotherapy consisting of paclitaxel and carboplatin entered the study. Patients were tested with resting EEG (R-EEG) before and after chemotherapy.
Twenty of the 28 patients responded to the chemotherapy (71%). Eleven patients (39%) developed peripheral neurotoxicity. A decrease of beta power and an increase of delta and theta power as well as a deceleration of the total centroid frequency clearly demonstrated a reduced vigilance in patients with ovarian cancer compared to healthy controls. On the other hand, the observed increase of beta power, a decrease of delta and theta power, and an acceleration of the total centroid from pre- to post-treatment demonstrated an improvement of vigilance in patients with ovarian cancer after treatment with paclitaxel/carboplatin.
The results of this study suggest that chemotherapy consisting of paclitaxel and carboplatin does not cause adverse effects on the central nervous system. Improved vigilance was measured in patients with ovarian cancer after chemotherapy.
本研究的目的是评估含紫杉醇的化疗方案对卵巢癌女性中枢神经系统（CNS）的可能影响。
28例经组织学证实为上皮性卵巢癌并接受紫杉醇和卡铂联合化疗的女性进入本研究。患者在化疗前后接受静息脑电图（R-EEG）检测。
28例患者中有20例对化疗有反应（71%）。11例患者（39%）出现外周神经毒性。与健康对照相比，卵巢癌患者β波功率降低、δ波和θ波功率增加以及总质心频率减慢，清楚地表明其警觉性降低。另一方面，观察到治疗前至治疗后β波功率增加、δ波和θ波功率降低以及总质心加速，表明卵巢癌患者在接受紫杉醇/卡铂治疗后警觉性有所改善。
本研究结果表明，紫杉醇和卡铂联合化疗不会对中枢神经系统产生不良影响。化疗后卵巢癌患者的警觉性有所提高。
