羊水和血浆中的组织因子（TF）及组织因子途径抑制物（TFPI）：对羊水栓塞机制的启示
Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in amniotic fluid and blood plasma: implications for the mechanism of amniotic fluid embolism.
作者信息
Uszyński M, Zekanowska E, Uszyński W, Kuczyński J
机构信息
Department of Medical Propedeutics, Ludwik Rydygier Medical University, Bydgoszcz, Poland.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2001 Apr;95(2):163-6. doi: 10.1016/s0301-2115(00)00448-6.
UNLABELLED
Tissue factor (TF) is known to be present in a high concentration in amniotic fluid. The main question of this study is whether tissue factor pathway inhibitor (TFPI), a natural inhibitor of TF, is present in amniotic fluid. The study group consisted of 28 women with normal pregnancy course, and at the first stage of termed labour. Fifteen non-pregnant women were the control group. TF and TFPI were studied by an immunoenzymatic method (ELISA). The level of TFPI in amniotic fluid was 38.7% of that in blood plasma (16.81+/-5.34ng/ml versus 43.41+/-18.70ng/ml, P<0.001), while the level of TF in amniotic fluid was 44.8 times higher than in blood plasma (9995.93+/-8533.11pg/ml versus 252.66+/-28.84pg/ml, P<0.001).
CONCLUSIONS
(i) It was found, for the first time, that amniotic fluid contains TFPI (ii) It is reasonable to assume that the intrusion of amniotic fluid into the blood-stream may influence the plasmatic TFPI-TF equilibrium resulting in intravascular blood coagulation.
未标记
已知组织因子（TF）在羊水中高浓度存在。本研究的主要问题是组织因子途径抑制剂（TFPI），一种TF的天然抑制剂，是否存在于羊水中。研究组由28名妊娠过程正常且处于足月分娩第一阶段的女性组成。15名未怀孕女性作为对照组。采用免疫酶法（ELISA）研究TF和TFPI。羊水中TFPI水平为血浆中TFPI水平的38.7%（16.81±5.34ng/ml对43.41±18.70ng/ml，P<0.001），而羊水中TF水平比血浆中高44.8倍（9995.93±8533.11pg/ml对252.66±28.84pg/ml，P<0.001）。
结论
（i）首次发现羊水含有TFPI；（ii）有理由推测羊水进入血流可能影响血浆TFPI-TF平衡，导致血管内凝血。
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