• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

关于马来酸盐对大鼠肾线粒体作用的机制。对底物水平磷酸化的影响。

On the mechanism of maleate action on rat kidney mitochondria. Effect on substrate-level phosphorylation.

作者信息

Pacanis A, Rogulski J, Ledóchowski H, Angielski S

出版信息

Acta Biochim Pol. 1975;22(1):1-10.

PMID:1130157
Abstract
  1. Maleate inhibits the substrate-level phosphorylation linked to anaerobic dismutation of 2-oxoglutarate in rat kidney mitochondria. 2. Phosphate and magnesium diminish the inhibitory effect of maleate. Arsenate also relieves the inhibition of 2-oxoglutarate consumption but only at low (1 mM) phosphate concentration; at higher concentrations, the action of phosphate and arsenate is competitive. 3. Acetoacetate, malonate and succinate, the substrates of CoA-transferase, relieve the inhibition of 2-oxoglutarate metabolism by maleate both in the respiring mitochondria and in the "anaerobic" system containing antimycin and rotenone. 4. The interference in succinyl-CoA metabolism by maleate is discussed as a possible mechanism of the inhibitory action of this compound.
摘要
  1. 马来酸盐抑制大鼠肾线粒体中与2-氧代戊二酸厌氧歧化相关的底物水平磷酸化。2. 磷酸盐和镁可减弱马来酸盐的抑制作用。砷酸盐也可减轻对2-氧代戊二酸消耗的抑制，但仅在低（1 mM）磷酸盐浓度下；在较高浓度下，磷酸盐和砷酸盐的作用是竞争性的。3. 辅酶A转移酶的底物乙酰乙酸、丙二酸和琥珀酸盐，在呼吸的线粒体和含有抗霉素和鱼藤酮的“厌氧”系统中，均可减轻马来酸盐对2-氧代戊二酸代谢的抑制。4. 讨论了马来酸盐对琥珀酰辅酶A代谢的干扰，作为该化合物抑制作用的一种可能机制。

相似文献

1
On the mechanism of maleate action on rat kidney mitochondria. Effect on substrate-level phosphorylation.关于马来酸盐对大鼠肾线粒体作用的机制。对底物水平磷酸化的影响。
Acta Biochim Pol. 1975;22(1):1-10.
2
On the mechanism of maleate action on rat kidney mitochondria. Effect on oxidative metabolism.关于马来酸盐对大鼠肾线粒体作用的机制。对氧化代谢的影响。
Acta Biochim Pol. 1974;21(4):403-13.
3
[Induction of the beta and gamma states of the comuton regulation of mitochondrial oxidative phosphorylation by inorganic phosphate].[无机磷酸盐对线粒体氧化磷酸化共调控的β和γ状态的诱导作用]
Izv Akad Nauk SSSR Biol. 1988 Jan-Feb(1):133-7.
4
[The induction of the beta state of the comuton regulation of mitochondrial oxidative phosphorylation by 2,4-DNP and malonate].[2,4-二硝基苯酚和丙二酸对线粒体氧化磷酸化共调节β状态的诱导作用]
Izv Akad Nauk SSSR Biol. 1989 Nov-Dec(6):926-30.
5
Phosphorylation of protein in liver and kidney mitochondria of the rat.
Acta Biochim Pol. 1968;15(4):307-15.
6
[The effect of alpha-ketoglutarate and ammonia ions on the oxidation of succinate by liver mitochondria].[α-酮戊二酸和铵离子对肝线粒体琥珀酸氧化的影响]
Biokhimiia. 1968 May-Jun;33(3):553-60.
7
Inactivation of coupled respiration of mitochondria by inorganic arsenate and partial restoration by ATP.无机砷酸盐使线粒体偶联呼吸失活，ATP使其部分恢复。
Biochem Biophys Res Commun. 1972 Nov 1;49(3):690-7. doi: 10.1016/0006-291x(72)90466-4.
8
[Induction of beta- and gamma-states of the comuton regulation of mitochondrial oxidative phosphorylation by calcium ions].[钙离子对线粒体氧化磷酸化共通调节的β态和γ态的诱导作用]
Izv Akad Nauk SSSR Biol. 1986 May-Jun(3):400-9.
9
[Study of the phosphorylating activity of isolated nuclear membranes of the rat liver].[大鼠肝脏分离核膜磷酸化活性的研究]
Biokhimiia. 1974 Jul-Aug;39(4):762-70.
10
Substrate specificity of succinyl-CoA transferase from rat kidney mitochondria.大鼠肾线粒体琥珀酰辅酶A转移酶的底物特异性
Acta Biochim Pol. 1977;24(1):3-11.

引用本文的文献

1
Maleate effects on kidney peptidases and proteinuria of male and female rats. Histochemical and biochemical studies.马来酸盐对雄性和雌性大鼠肾脏肽酶及蛋白尿的影响。组织化学和生物化学研究。
Histochemistry. 1985;82(1):81-92. doi: 10.1007/BF00502094.