埃坡霉素的生物合成研究：聚酮合酶和埃坡霉素C/D单加氧酶

Studies on the biosynthesis of epothilones: the PKS and Epothilone C/D monooxygenase.

作者信息

Gerth K, Steinmetz H, Höfle G, Reichenbach H

机构信息

GBF, Gesellschaft für Biotechnologische Forschung mbH, Abteilung Naturstoffbiologie, Braunschweig, Germany.

出版信息

J Antibiot (Tokyo). 2001 Feb;54(2):144-8. doi: 10.7164/antibiotics.54.144.

DOI:10.7164/antibiotics.54.144

PMID:11302486

Abstract

Nonproducer mutants support the assumption that epothilones A and B are synthesized by the same polyketide synthase (PKS). The endproducts of the PKS, epothilones C and D, compete for the active site of a constitutively synthesized monooxygenase which is regulated by product inhibition. The postulated C-13 hydroxy-epothilones as direct precursors of epothilones C and D were not detected.

摘要

非产生突变体支持埃坡霉素A和B由同一聚酮合酶（PKS）合成的假设。PKS的终产物埃坡霉素C和D，竞争由产物抑制调节的组成型合成单加氧酶的活性位点。未检测到假定的作为埃坡霉素C和D直接前体的C-13羟基埃坡霉素。