Tuazon C U, Sheagren J N
Am J Med Sci. 1975 Jan-Feb;269(1):145-8. doi: 10.1097/00000441-197501000-00016.
A 25-year-old black female heroin addict presented with Staphylococcus aureus endocarditis. Because of a history of penicillin allergy, therapy was gegun with cephalothin (Keflin); lack of clinical response led to the use of clindamycin. Response was excellent. After six weeks of treatment she was discharged well, only to return six days later with recurrent endocarditis. The organism, confirmed by sensitivity and phage typing, was identifcal to that causing the inital episode. This patient illustrates the apparent failure of clindamycin to eradicate a deep-seated intravascular infection with a sensitive organism.
一名25岁的黑人女性海洛因成瘾者患金黄色葡萄球菌性心内膜炎。由于有青霉素过敏史，开始用头孢噻吩（凯福林）治疗；缺乏临床反应导致改用克林霉素。反应良好。治疗六周后她康复出院，但六天后因复发性心内膜炎再次入院。经敏感性和噬菌体分型确认，病原体与引起初次发作的病原体相同。该患者表明，克林霉素在根除由敏感病原体引起的深部血管内感染方面似乎无效。
