Fan X Q, Guo Y J
International Joint Cancer Institute, The Second Military Medical University, Shanghai, China.
Cell Res. 2001 Mar;11(1):1-7. doi: 10.1038/sj.cr.7290060.
Apoptosis is a complex process involving a large array of genes and mutation of any of these genes may lead to malignancy formation. Re-acquirement of FasL by tumor cells may enable them to evade the surveillance of immune system and thus contributes to the growth of tumor. Apart from traditional therapies, inducing apoptosis of tumor cell by new methods employing death receptor ligands and making use of Fas counterattack is also being developed.
细胞凋亡是一个复杂的过程,涉及大量基因,这些基因中的任何一个发生突变都可能导致恶性肿瘤的形成。肿瘤细胞重新获得FasL可能使其能够逃避免疫系统的监视,从而促进肿瘤生长。除了传统疗法外,利用死亡受体配体通过新方法诱导肿瘤细胞凋亡并利用Fas反击也正在研发中。