HOX基因在鸡基因组中的分布揭示了人类和鸡之间新的保守片段。

Distribution of HOX genes in the chicken genome reveals a new segment of conservation between human and chicken.

作者信息

Ladjali-Mohammedi K, Grapin-Botton A, Bonnin M A, Le Douarin N M

机构信息

Institut d'Embryologie Cellulaire et Moléculaire du CNRS et Collège de France, Nogent-sur-Marne, France.

出版信息

Cytogenet Cell Genet. 2001;92(1-2):157-61. doi: 10.1159/000056889.

DOI:10.1159/000056889

PMID:11306817

Abstract

Homeobox genes play an important role in the regulation of early embryonic development. They represent a family of evolutionarily highly conserved transcription factors. In this work, several genes that belong to the four HOX gene clusters are assigned by in situ hybridization to four distinct chicken chromosomes. The four gene clusters are mapped to 2p2.1 (HOXA), 3q3.1 (HOXB), 1q3.1 (HOXC) and 7q1.3--> q1.4 (HOXD). We confirm partial homologies already detected by genetic mapping between chicken chromosomes 1, 2 and 7 and human chromosomes 12, 7 and 2 and we describe a new conserved segment between chicken chromosome 3 and human chromosome 17. These results represent the first data that confirm the physical linkage between chicken HOX genes and may improve our understanding of phylogenetic relationships and genome evolution.

摘要

同源框基因在早期胚胎发育的调控中发挥着重要作用。它们代表了一类在进化上高度保守的转录因子家族。在这项工作中，通过原位杂交将属于四个HOX基因簇的几个基因定位到四条不同的鸡染色体上。这四个基因簇被定位到2p2.1（HOXA）、3q3.1（HOXB）、1q3.1（HOXC）和7q1.3→q1.4（HOXD）。我们证实了通过遗传图谱已经检测到的鸡的1号、2号和7号染色体与人类的12号、7号和2号染色体之间的部分同源性，并且我们描述了鸡的3号染色体与人类的17号染色体之间一个新的保守区段。这些结果代表了首批证实鸡HOX基因之间物理连锁的数据，并且可能增进我们对系统发育关系和基因组进化的理解。