Yanagida H, Ashizawa N, Wakushima Y, Yamamura H
Anesthesiology. 1975 May;42(5):574-83. doi: 10.1097/00000542-197505000-00012.
Effects of anesthetics and doxapram on pontogeniculo-occipital (PGO) waves from the oculomotor nucleus were studied in acute experiments in cats paralyzed by gallamine triethiodide. The anesthetic agents studied in the present experiment (thiopental, ketamine, Innovar, nitrous oxide, and halothane) decreased, while doxapram increased, the total number of PGO waves. As the doses of anesthetics increased, PGO waves were abolished, but they returned to control levels or below control levels when the concentrations of anesthetics were decreased. The results indicate that the anesthetics studied inhibit the activity of the central mechanism associated with the oculomotor system. PGO waves may prove a useful index of the level of anesthesia.
在三碘季铵酚麻痹的猫的急性实验中，研究了麻醉剂和多沙普仑对动眼神经核的脑桥膝状体枕部（PGO）波的影响。本实验中研究的麻醉剂（硫喷妥钠、氯胺酮、氟哌利多芬太尼合剂、氧化亚氮和氟烷）使PGO波的总数减少，而多沙普仑使其增加。随着麻醉剂剂量的增加，PGO波消失，但当麻醉剂浓度降低时，PGO波恢复到对照水平或低于对照水平。结果表明，所研究的麻醉剂抑制与动眼系统相关的中枢机制的活动。PGO波可能是麻醉深度的一个有用指标。
