氯氮平所致中毒性肝炎
[Clozapine-induced toxic hepatitis].
作者信息
Larsen J T, Clemensen S V, Klitgaard N A, Nielsen B, Brøsen K
机构信息
Odense Universitetshospital, afdeling KKA, sektion for klinisk farmakologi og psykiatrisk afdeling P.
出版信息
Ugeskr Laeger. 2001 Apr 2;163(14):2013-4.
A case of clozapine-induced toxic hepatitis in a 49-year old woman with schizophrenia is described. The daily clozapine dose was clinically titrated to 300 mg. Subsequently, the patient experienced lethargy and anorexia, and fever, eosinophilia, leucocytosis and abnormal liver parameters were found. The serum concentration of clozapine was 8595 nmol/l, and treatment was discontinued. After eight days, the condition stabilised, and low-dose clozapine treatment was successfully reinstituted with serum monitoring (TDM).
描述了一例49岁精神分裂症女性患者因氯氮平导致中毒性肝炎的病例。氯氮平的每日剂量经临床滴定至300毫克。随后，患者出现嗜睡、厌食，并且发现发热、嗜酸性粒细胞增多、白细胞增多及肝脏参数异常。氯氮平的血清浓度为8595纳摩尔/升，于是停用治疗。八天后病情稳定，通过血清监测（治疗药物监测）成功重新开始了小剂量氯氮平治疗。
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