Pérez J, Dellinger R P
Division of Cardiovascular and Critical Care Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Ill., USA.
Intensive Care Med. 2001;27 Suppl 1:S116-27. doi: 10.1007/pl00003793.
Patients who survive the circulatory and organ deficits in sepsis may still fall victim to complications such as pulmonary embolism and stress ulcer bleeding. Although there is no clearcut evidence to quantitate the impact of such complications on mortality, the anticipated impact is grave when considering the compromised physiological reserve of these patients. For this reason it is important to institute effective prophylaxis to minimize the impact. In addition, catabolism associated with sepsis likely influences the recovery of patients with sepsis and moreover can compromise the response of the immune system against an infectious insult. Early and adequate nutritional support therefore appears important. There is much controversy and lack of prospective research regarding effect of supportive therapies on outcome in patients with severe sepsis. This research is needed.
在脓毒症中循环和器官功能缺损后存活下来的患者，仍可能成为诸如肺栓塞和应激性溃疡出血等并发症的受害者。尽管没有明确的证据来量化这些并发症对死亡率的影响，但考虑到这些患者生理储备受损，预期影响是严重的。因此，采取有效的预防措施以尽量减少影响非常重要。此外，与脓毒症相关的分解代谢可能会影响脓毒症患者的康复，而且还会损害免疫系统对感染性损伤的反应。因此，早期和充足的营养支持显得很重要。关于支持性治疗对严重脓毒症患者预后的影响，存在很多争议且缺乏前瞻性研究。这方面的研究是必要的。
