Malit L A, Johnstone R E, Bourke D I, Kulp R A, Klein V, Smith T C
Anesthesiology. 1975 Jun;42(6):666-73.
Delta9-Tetrahydrocannabinol (THC), the active component of marijuana, was studies to determine whether it might be useful for preanesthetic medication. Ten healthy subjects received THC intravenously in logarithmically spaced incremental doses. Four subjects received a total cumulatine dose of 135 mug/kg and four others, 201 mug/kg, Two of the ten subjects discontinued the study because of anxiety reactions. Ventilatory minute volume at a controlled elevated CO2 tension, 48 plus or minus 2 (SD) torr, changed minimally with TCH, -0.49 1/min/50 per cent increase in dose. TCH shifted the ventilatory response to CO22.7 torr destrad at 20 1/min without a change in slope. Dose-related tachycardia was the most marked cardiovascular effect. Heart rates increased to more than 100/min in five of six subjects. Cardiac index increased from 4.04 plus or minus 0.62 1/min/m-2 before TCH to 6.92 plus or minus 2.34 1/min/m-2 after 134 mug/kg. Mean arterial pressure increased slightly, and total peripheral resistance fell. The cardiovascular changes suggest beta-adrenergic stimulation. Intense mental effects and anxiety prohibited higher THC doses.
大麻的活性成分Δ9-四氢大麻酚（THC）被用于研究其是否可用于麻醉前用药。10名健康受试者静脉注射递增剂量的THC，剂量按对数间距递增。4名受试者接受的总累积剂量为135μg/kg，另外4名受试者为201μg/kg。10名受试者中有2名因焦虑反应而中断研究。在控制的二氧化碳分压升高至48±2（标准差）托时，每分钟通气量随THC的变化极小，剂量每增加50%，每分钟通气量减少0.49升/分钟。THC使对二氧化碳的通气反应在每分钟20升时右移2.7托，斜率无变化。与剂量相关的心动过速是最明显的心血管效应。6名受试者中有5名心率增加到超过100次/分钟。心脏指数从THC给药前的4.04±0.62升/分钟/平方米增加到134μg/kg给药后的6.92±2.34升/分钟/平方米。平均动脉压略有升高，总外周阻力下降。心血管变化提示β-肾上腺素能刺激。强烈的精神效应和焦虑使得无法使用更高剂量的THC。
