Cheng P C, Cherukuri A, Dykstra M, Malapati S, Sproul T, Chen M R, Pierce S K
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA.
Semin Immunol. 2001 Apr;13(2):107-14. doi: 10.1006/smim.2000.0302.
The initiation of antibody responses to foreign antigens requires that B cells receive and integrate a variety of signals through an array of cell surface receptors including the B cell antigen receptor (BCR) as well as a number of essential coreceptors. Recent evidence indicates that cholesterol-rich plasma membrane microdomains, referred to here as lipid rafts, serve as platforms for BCR signaling and trafficking in B cells. The existence of rafts suggests a previously unappreciated level of organization at the B cell surface that may explain, at least in part, how BCR signaling is coordinated. Here the current evidence that lipid rafts play a key role in B cell responses is reviewed.
对外源抗原产生抗体反应需要B细胞通过一系列细胞表面受体接收并整合多种信号，这些受体包括B细胞抗原受体（BCR）以及一些重要的共受体。最近的证据表明，富含胆固醇的质膜微结构域（本文称为脂筏）作为B细胞中BCR信号传导和运输的平台。脂筏的存在表明B细胞表面存在一种以前未被重视的组织水平，这可能至少部分解释了BCR信号是如何协调的。本文综述了脂筏在B细胞反应中起关键作用的现有证据。
