Buckwalter J A, Thomas C G, Freeman J B
Ann Surg. 1975 May;181(5):632-9. doi: 10.1097/00000658-197505000-00018.
The clinical, pathological, surgical, postoperative findings and survivorship of 58 patients younger and 513 patients older than 21 years at the time of diagnosis with thyroid neoplasms are reported. The younger patients have a predominance of well differentiated carcinomas which are more likely to be follicular. The lesions tend to be more advanced at the time of diagnosis, are treated by more aggressive surgery in the younger patients and are associated with a much better prognosis. Lack of progression of well to poorly differentiated neoplasms and a greater sensitivity to and dependence upon TSH in young patients, are two factors which may contribute to the striking difference in the prognosis of well differentiated thyroid carcinoma related to age.
报告了58例诊断时年龄小于21岁及513例年龄大于21岁的甲状腺肿瘤患者的临床、病理、手术、术后情况及生存情况。年轻患者中高分化癌占优势，且更可能为滤泡状癌。这些病变在诊断时往往处于更晚期，年轻患者接受更积极的手术治疗，且预后要好得多。高分化肿瘤未进展为低分化肿瘤以及年轻患者对促甲状腺激素（TSH）更敏感且依赖TSH，是可能导致高分化甲状腺癌预后与年龄相关的显著差异的两个因素。
