O'branski E E, Ware R E, Prose N S, Kinney T R
Duke University Pediatric Sickle Cell Program and Division of Hematology/Oncology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.
J Am Acad Dermatol. 2001 May;44(5):859-61. doi: 10.1067/mjd.2001.113471.
Skin and nail changes from long-term hydroxyurea therapy are reported in adults. Skin and nail changes, including nail hyperpigmentation, longitudinal bands, and hyperpigmentation of the palms and other skin surfaces, developed in 7 children with sickle cell anemia after 6 to 16 weeks of hydroxyurea therapy. Cutaneous and nail changes may occur in children receiving hydroxyurea.
据报道，长期使用羟基脲治疗会导致成人皮肤和指甲出现变化。7名镰状细胞贫血患儿在接受羟基脲治疗6至16周后，出现了皮肤和指甲变化，包括指甲色素沉着、纵纹以及手掌和其他皮肤表面色素沉着。接受羟基脲治疗的儿童可能会出现皮肤和指甲变化。
