Sharp D E, Berge M A, Paust D E, Talaat R E, Wilkes L C, Servatius L J, Loftus M L, Caravello H E, Parent R A
Covance Laboratories Inc., P.O. Box 7545, Madison, WI 53707, USA.
J Agric Food Chem. 2001 Mar;49(3):1630-8. doi: 10.1021/jf000078z.
The metabolism and distribution of [2,3-(14)C]acrolein were studied in a lactating goat orally administered 0.82 mg/kg of body weight/day for 5 days. Milk, urine, feces, and expired air were collected. The goat was killed 12 h after the last dose, and edible tissues were collected. The nature of the radioactive residues was determined in milk and tissues. All of the identified metabolites were the result of the incorporation of acrolein into the normal, natural products of intermediary metabolism. There was evidence that the three-carbon unit of acrolein was incorporated intact into glucose, and subsequently lactose, and into glycerol. In the case of other natural products, the incorporation of radioactivity appeared to result from the metabolism of acrolein to smaller molecules followed by incorporation of these metabolites into the normal biosynthetic pathways.
对一只泌乳山羊进行了研究，该山羊每天经口给予0.82毫克/千克体重的[2,3-(14)C]丙烯醛，持续5天。收集了牛奶、尿液、粪便和呼出的气体。在最后一剂给药12小时后处死山羊，并收集可食用组织。测定了牛奶和组织中放射性残留物的性质。所有鉴定出的代谢物都是丙烯醛掺入中间代谢的正常天然产物的结果。有证据表明，丙烯醛的三碳单元完整地掺入葡萄糖，随后掺入乳糖和甘油。在其他天然产物的情况下，放射性的掺入似乎是由于丙烯醛代谢为较小的分子，然后这些代谢物掺入正常的生物合成途径。
