Long X, Li J
Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Hubei Medical University, 65 Luoyu Road, Wuhan, Hubei, 430079, P. R. China.
Chin J Dent Res. 2000 Aug;3(2):53-7.
To create an animal model of anterior disc displacement of temporomandibular joint (TMJ) for studying the pathologic change of anterior disc displacement.
The disc was surgically displaced anteriorly in the right temporomandibular joint in each of 25 rabbits. The outer capsular of anterior attachment of disc was exposed through the floor of the orbit and the temporal extension of the anterior band of disc was sutured to the zygomatic arch. The left side was approached in a similar manner except for repositioning the disc anteriorly. Five additional rabbits served as non-surgical controls. The animals were sacrificed at 1, 2, 4, 8, and 12 weeks after surgery. The histological changes were observed.
Microscopic observation showed 11 joints with partial anterior disc displacement, 8 joints with complete anterior disc displacement, and 6 joints with perforation of disc in the surgical groups. The histological changes included physiologic remodeling or early degenerative changes in the partial anterior disc displacement joints, degenerative changes in the complete disc displacement joints, and severe osteoarthritic changes in the perforated joints.
The degree of anterior disc displacement caused different kinds of osteoarthritic changes in the articular cartilage of the experimental animals.
建立颞下颌关节盘前移位动物模型，以研究盘前移位的病理变化。
对25只家兔的右侧颞下颌关节进行手术，使关节盘向前移位。通过眶底暴露关节盘前附着的外侧关节囊，将关节盘前带的颞侧延伸部分缝合至颧弓。左侧以类似方式处理，但不将关节盘向前移位。另外5只家兔作为非手术对照。术后1、2、4、8和12周处死动物，观察组织学变化。
显微镜观察显示，手术组中11个关节为部分盘前移位，8个关节为完全盘前移位，6个关节为关节盘穿孔。组织学变化包括部分盘前移位关节的生理性重塑或早期退变改变，完全盘移位关节的退变改变，以及穿孔关节的严重骨关节炎改变。
盘前移位程度在实验动物的关节软骨中引起了不同类型的骨关节炎改变。
