Si X H
Department of Endodontics, School of Stomatology, Shanghai Second Medical University, Shanghai 200011, P. R. China.
Chin J Dent Res. 2000 Nov;3(3):40-3.
To elucidate the expression and significance of cell cycle-associated proteins in chondrosarcoma of the jaws.
CDK4, p27, and E2F-1 expression were examined in chondrosarcoma and osteochondroma of the jaws by immunohistochemical ABC method.
CDK4, p27, and E2F-1 were positive in 60% (12 of 20), 25% (5 of 20), and 65% (13 of 20), respectively, in chondrosarcoma of the jaws. There was no significant difference in the expression of CDK4, P27, and E2F-1 among histological grade of the chondrosarcoma (P > 0.05). In osteochondroma of the jaws, CDK4 and E2F-1 showed an equal positivity of 12.5% (1 of 8), whereas p27 was positive in 87.5% (7 of 8). The positive rate of CDK4, p27, and E2F-1 was significant between chondrosarcoma and osteochondroma of the jaws (P < 0.05).
These data show that cell cycle regulatory proteins are altered in chondrosarcoma of the jaws. CDK4 and E2F-1 are over-expressed and p27 is under-expressed in chondrosarcoma of the jaws.
阐明细胞周期相关蛋白在颌骨软骨肉瘤中的表达及意义。
采用免疫组织化学ABC法检测颌骨软骨肉瘤及骨软骨瘤中CDK4、p27和E2F-1的表达。
颌骨软骨肉瘤中CDK4、p27和E2F-1的阳性率分别为60%（20例中的12例）、25%（20例中的5例）和65%（20例中的13例）。软骨肉瘤不同组织学分级中CDK4、P27和E2F-1的表达无显著差异（P>0.05）。在颌骨骨软骨瘤中，CDK4和E2F-1的阳性率均为12.5%（8例中的1例），而p27的阳性率为87.5%（8例中的7例）。颌骨软骨肉瘤与骨软骨瘤中CDK4、p27和E2F-1的阳性率差异有统计学意义（P<0.05）。
这些数据表明，颌骨软骨肉瘤中细胞周期调节蛋白发生改变。在颌骨软骨肉瘤中，CDK4和E2F-1过度表达，p27表达不足。
