尼氟灭酸与儿童皮肤反应
Niflumic acid and cutaneous reactions in children.
作者信息
Menniti-Ippolito F, Sagliocca L, Da Cas R, Saggiomo G, Di Nardo R, Traversa G
机构信息
Department of Epidemiology and Biostatistics, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
出版信息
Arch Dis Child. 2001 May;84(5):430-1. doi: 10.1136/adc.84.5.430.
In a case control study of adverse drug reactions in children, the odds ratio of developing a serious mucocutaneous event among users of niflumic acid, adjusted for concomitant use of all other drugs, was 4.9 (95% CI 1.9 to 12.8). Given the availability of safer analgesics and antipyretics, there is no indication, in our opinion, that requires the prescription of substances which bear an increased risk.
在一项关于儿童药物不良反应的病例对照研究中，在考虑所有其他药物合并使用情况进行调整后，使用尼氟酸的儿童发生严重黏膜皮肤事件的优势比为4.9（95%置信区间为1.9至12.8）。鉴于有更安全的止痛和退热药物可供使用，我们认为，没有迹象表明需要开具具有更高风险的药物。
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