Baek T M, Lee K H, Tomidokoro A, Oshika T
St Mary's Eye Hospital, Pusan, Korea.
Br J Ophthalmol. 2001 May;85(5):534-6. doi: 10.1136/bjo.85.5.534.
To quantitatively evaluate the changes in corneal irregular astigmatism after laser in situ keratomileusis (LASIK) in relation to the amount of laser ablation.
In 189 eyes of 116 patients undergoing LASIK for myopia, corneal topography was obtained before and 1 month after surgery. Using Fourier harmonic analysis of the topography data, corneal irregular astigmatism (asymmetry and higher order irregularity) was calculated.
By surgery, asymmetry component significantly increased (p < 0.0001, Wilcoxon signed rank test), while higher order irregularity did not (p = 0.767). The increases in the asymmetry component significantly correlated with ablation depth (Spearman rank correlation coefficient r(s) = 0.440, p < 0.0001). No significant correlation was found between changes in higher order irregularity and ablation depth (r(s) = 0.137, p = 0.074).
LASIK significantly increases the asymmetry component of the cornea which is dependent on the amount of laser ablation.
定量评估准分子原位角膜磨镶术（LASIK）后角膜不规则散光与激光消融量之间的关系。
对116例接受LASIK治疗近视的患者的189只眼睛，在手术前及术后1个月获取角膜地形图。通过对地形图数据进行傅里叶谐波分析，计算角膜不规则散光（不对称性和高阶不规则性）。
手术前后比较，不对称性成分显著增加（p < 0.0001，Wilcoxon符号秩检验），而高阶不规则性无明显变化（p = 0.767）。不对称性成分的增加与消融深度显著相关（Spearman等级相关系数r(s)= 0.440，p < 0.0001）。高阶不规则性的变化与消融深度之间未发现显著相关性（r(s)= 0.137，p = 0.074）。
LASIK显著增加角膜的不对称性成分，且该成分取决于激光消融量。
