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Identification of phosphorodiamidic acid mustard as a human metabolite of cyclop hosphamide.

作者信息

Fenselau C, Kan M N, Billets S, Colvin M

出版信息

Cancer Res. 1975 Jun;35(6):1453-7.

PMID:1131817
Abstract

An active metabolite of cyclophosphamide, N,N-bis(2-chloroethyl)phosphorodiamidic acid, has been confirmed as a circulating and excreted metabolite in patients receiving the drug in therapy, by selected ion monitoring on a gas chromatograph mass spectrometer.

摘要

相似文献

1
Identification of phosphorodiamidic acid mustard as a human metabolite of cyclop hosphamide.
Cancer Res. 1975 Jun;35(6):1453-7.
2
Quantification by gas chromatography of N,N'-di-(2-chloroethyl)-phosphorodiamidic acid in the plasma of patients receiving isophosphamide.
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Quantitation by gas chromatography-chemical ionization mass spectrometry of cyclophosphamide, phosphoramide mustard, and nornitrogen mustard in the plasma and urine of patients receiving cyclophosphamide therapy.采用气相色谱-化学电离质谱法对接受环磷酰胺治疗的患者血浆和尿液中环磷酰胺、磷酰胺氮芥和去甲氮芥进行定量分析。
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5
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Metabolite Profiling in Anticancer Drug Development: A Systematic Review.代谢组学在抗癌药物研发中的应用：系统评价。
Drug Des Devel Ther. 2020 Apr 9;14:1401-1444. doi: 10.2147/DDDT.S221518. eCollection 2020.
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Clinical pharmacokinetics of commonly used anticancer drugs.常用抗癌药物的临床药代动力学
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4
Kinetics of hydrolysis in vitro of nornitrogen mustard, a metabolite of phosphoramide mustard and cyclophosphamide.
Arch Toxicol. 1987 Dec;61(2):126-30. doi: 10.1007/BF00661370.
5
[Permeability of N,N-bis(2-chloroethyl)-diamido-phosphoric-acid into tumor cells (author's transl)].N,N-双（2-氯乙基）-二氨基磷酸对肿瘤细胞的通透性（作者译）
J Cancer Res Clin Oncol. 1979 Feb 19;93(2):161-4. doi: 10.1007/BF00406573.