Autian J, Singh A R, Turner J E, Hung G W, Nunez L J, Lawrence W H
Cancer Res. 1975 Jun;35(6):1591-6.
Seventeen polyurethans, containing various substituent groups, and a polyethylene were implanted i.p. in groups of male black Bethesda rats and were evaluated for carcinogenesis over a 2-year period. Thirteen of the polyurethans and the polyethylene were similarly studied in females. Tumor development in these animals was expressed in terms of the incidence in the at-risk population, and the tumorigenic latent period was approximated for each sample. Twenty months after implantation, the relative tumorigenicity (area under the corrected cumulative tumor mortality versus time curve) in the males ranged from 0 (for the unimplanted controls) to 6.18 (for Y-238); for female rats this range was 0.29 (for unimplanted controls) to 5.72 (for Y-238). Estimated latent periods in the males ranged from 5 months (for Y-304) to 16 months (for Y-303), and 22.5 months for the unimplanted controls; for the females, the range was from 9 months (for Y-290) to 13.5 months (for Y-217), and 14 months for the unimplanted controls. The relative tumorigenicity of each sample was also compared to its in vitro activation energy for thermal decomposition. These data are discussed in terms of solid-state versus chemical carcinogenesis.
将含有各种取代基的17种聚氨酯和1种聚乙烯腹腔注射到雄性黑色贝塞斯达大鼠组中，并在2年的时间里评估其致癌性。对其中13种聚氨酯和聚乙烯在雌性大鼠中进行了类似的研究。这些动物的肿瘤发生情况以高危群体中的发病率表示，并估算每个样本的致瘤潜伏期。植入后20个月，雄性大鼠的相对致瘤性（校正后的累积肿瘤死亡率与时间曲线下的面积）范围为0（未植入的对照组）至6.18（Y - 238）；雌性大鼠的这一范围为0.29（未植入的对照组）至5.72（Y - 238）。雄性大鼠的估计潜伏期范围为5个月（Y - 304）至16个月（Y - 303），未植入的对照组为22.5个月；雌性大鼠的范围为9个月（Y - 290）至13.5个月（Y - 217），未植入的对照组为14个月。还将每个样本的相对致瘤性与其热分解的体外活化能进行了比较。根据固态致癌与化学致癌对这些数据进行了讨论。
